Green Synthesis of Silver Nanoparticles as a Wound Healing Agent: a Systematic Review of the Biological Activities

Background: The implication of nanotechnology includes silver nanoparticles to medical sciences, and has a revolutionary impact on therapeutic diagnostics management. Many studies reported that nanoparticle (AgNPs) application can accelerate the wound healing process. This study aimed systematically review biological activities as wound-healing agent. Subjects Method: article was systematic conducted by searching for articles from online databases such EBSCO, PubMed, Science Direct, World Scientific. Populations: laboratory animals; Intervention: green synthesis nanoparticles; Comparison: standard ointment wounds povidone-iodine, etc; Outcome: healing. independent variable is nanoparticles, dependent inclusion criteria this were full using an experimental study, with publication year until 2022. data extraction focused following Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) recommendations reviews. Results: A total 8 reviewed in countries: Egypt, India, Saudi Arabia, Singapore, China. AgNPs accomplished natural aqueous extract leaves Azadirachta indica, Tridax procumbens, combinations Catharanthus roseus Scutellaria barbata, fungus Fusarium verticillioides, or cyanobacterial platforms (ex: Phormidium sp., Synechocystis sp, arthrospira sp polysaccharides). All animal-based infected bacteria inflicted regards experiment. trials resulted favor treated group compared untreated group. Conclusion: Our suggested all about efficacy therapy showed positive results. Keywords: activities, Correspondence: Galih Priambodo. Faculty Medicine, Universitas Diponegoro. Jl. Prof. Sudarto, Tembalang, Kec. Kota Semarang, Central Java. Email: [email protected]. Mobile: 085229998999. Indonesian Journal Medicine (2023), 08(01): 100-113 https://doi.org/10.26911/theijmed.2023.08.01.10